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KMID : 0613820050150040572
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Journal of Life Science
2005 Volume.15 No. 4 p.572 ~ p.577
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The Hepatoprotective Effects of Epimedii Herba through the Antioxidation
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Ha Bae-Jin
Kim Hee-Jin
Lee Sang-Hun
Ha Jong-Myuong
Lee Sang-Hyun
Lee Jae-Hwa
Lee Dong-Geun
Park Eun-Kyung
Nam Chun-Suk
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Abstract
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In this study, the effect of Epimedii Herba (EH) on the antioxidative enzymatic activity was investigated. EH (100 ㎎/㎏) was intraperitoneally administered into rats for 2 weeks. On the last day, carbon tetrachloride (50% CCl₄, 3.3 ml/㎏, i.p.) dissolved in olive oil was injected before 12 hours. EH-preadministered and CCl₄-treated (EC) group showed higher inhibitory effect in aminotransferase (AST, ALT) activity compared to CCl4-treated (CT) group. Superoxide dismutase (SOD) and Catalase in EC group were increased compared to those of CT group. The activity of glutathione peroxidase (GPx) was significantly higher than those of CT group compared to EC group. These results suggest that EH has a hepatoprotective effect through scavenging the free radicals induced by CCl₄
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